0273 : Role of Sirtuin 3 in cardioprotection – evolution with aging
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چکیده
منابع مشابه
The sirtuin family's role in aging and age-associated pathologies.
The 7 mammalian sirtuin proteins compose a protective cavalry of enzymes that can be invoked by cells to aid in the defense against a vast array of stressors. The pathologies associated with aging, such as metabolic syndrome, neurodegeneration, and cancer, are either caused by or exacerbated by a lifetime of chronic stress. As such, the activation of sirtuin proteins could provide a therapeutic...
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The yeast sirtuin (Sir2) is a histone deacetylase that modulates yeast replicative life span by suppressing genome instability through chromatin modification. In this issue, Oberdoerffer et al. (2008) report that SIRT1, the mammalian ortholog of Sir2, is involved in DNA damage-induced chromatin reorganization, which promotes genome stability in mammalian cells.
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ژورنال
عنوان ژورنال: Archives of Cardiovascular Diseases Supplements
سال: 2015
ISSN: 1878-6480
DOI: 10.1016/s1878-6480(15)30039-2